29 The downstream signaling of GPR55 remains to be fully elucidated; however, it is known to use Gα13 for signal transduction and to activate PLC, RhoA, ROCK, ERK, p38 mitogen activated protein kinase, and Ca2+ release that can induce downstream transcription factors such as NFAT, NF-κB, CREB, and ATF2.
The latter, however, is associated with the downstream release of endothelin 1 (Ethatthat is consistent with vasoconstriction.
"That's creating a downstream trough and that's really almost acting as a conveyor belt for the cold air".
Finally, removal of the leader peptide by a downstream protease releases the mature lanthipeptide.
Our data suggest that IF1 overexpression limits mitochondrial release of Cyt c, so that the downstream events that amplify Cyt c release and complete the apoptotic program are delayed.
Hypothetically, Pb could alter ACTH-dependent CORT release by affecting ACTH binding to the melanocortin receptor or the downstream pathways that lead to CORT release (Doufexis et al. 2007; Halkerston 1975), but further studies are needed to really understand our findings.
Moreover, siPuma transfection inhibited Smac release and confirmed that Smac release is a downstream event of Puma activation.
Water built up for hours before breaching on Monday, sending a torrent downstream that threatened farms and residents.
When the mu receptor is stimulated by an opioid, it releases chemicals that work downstream on parts of the brain that tell the body to slow down breathing, or even stop it altogether.
Are there any downstream mutations that lead to increased intracellular calcium release or enhanced downstream pathways?
The principle whereby an activated receptor can in turn, rapidly release a ligand that immediately 'transactivates' a downstream 'receptor cascade' is best illustrated by the agonist-driven release of nitric oxide, which immediately regulates tissue function.
