The phrase "a downmodulation in the expression of" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly in discussions about gene expression, protein levels, or cellular responses.
Example: "The study revealed a downmodulation in the expression of the target gene under stress conditions."
Alternatives: "a decrease in the expression of" or "a reduction in the expression of".
To further confirm the inhibition of cell growth mediated by PI3K/AKT pathway downmodulation, we analyzed the expression of the cell cycle marker Ki67 on LY294002 treated cells.
Considering this, the present study was designed to address whether the expression of proteins involved in the resistance to cytotoxic CD8+ T cells such as EPHRIN-A1 and/or SCINDERIN or the downmodulation of HLA-class I molecules, could explain the absence of clinical impact of intratumoral CD8+ T cell infiltration in head and neck cancer.
We assessed the expression of these putative targets in CommaDβ subpopulations after miR-34a manipulation: eight targets showed a coherent regulation, as they were downregulated after miR-34a overexpression in Scahigh cells, and upregulated after miR-34a downmodulation in Scalow cells (Fig. 5e).
(D) A cluster illustrating a downmodulation in SAPSII-low group only.
Of note, Pin1 downmodulation caused enhanced mRNA expression of the epithelial marker E-cadherin (CDH1) while that of mesenchymal markers Vimentin and Fibronectin (VIM1, FN) was reduced (Fig 2C, left panel), in parallel with a strong recovery of E-cadherin and decay of Slug and Vimentin at the protein level (Fig 2C, right panel).
In contrast, there was no significant downmodulation of cell surface expression of CD4 or CCR5 with any of the three defensins (data not shown).
Moreover, silencing experiments confirmed the central role of Apollon downmodulation in promoting the apoptotic response of melanoma cells to the combinatorial treatments.
Silencing experiments, by previously validated siRNA, confirmed the central role of Apollon downmodulation in promoting the apoptotic response of melanoma cells even to these combinatorial treatments.
Downmodulation of CD146 expression in the MDA-MB-231 cell line resulted in downmodulation of vimentin, as well as of a set of genes that include both genes associated with a poor prognosis in a variety of cancers and genes known to promote cell motility.
