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A recent trial from Bangladesh showed markedly more rapid atropinisation of OP-poisoned patients with a doubling dose regimen of atropine rather than a standard bolus dose regimen.
Furthermore, our point estimate of a reduction in PC20 of 0.48 of a doubling dose could potentially be of major public health significance.
Formaldehyde versus air-only exposure resulted in a PD20 methacholine that was lower in three subjects, higher in four, and unchanged (within a doubling dose) in five.
After controlling for baseline PC20, the difference (expressed as a doubling dose difference, paracetamol minus placebo) was not statistically significant: −0.48 (95% CI −1.28 to 0.32), p=0.24 (table 2).
We found that the infection improved BHR by half a doubling dose more than the placebo group, although the confidence interval was wide and the difference between the groups was not significant.
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Studies typically use two mice per dose level with a doubling dose-escalation or dose-halving de-escalation design.
"This is a double dose.
Morphine then, a double dose.
Defeat was a double dose of gall.
Get ready for a double dose.
"So my doctors recommended a double dose," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com