Manual changeover methods include the QC and the double infusion pump (DIP) technique.
In FEATURE, greater B cell repletion was found in the single infusion group at week 24, suggesting that the double infusion administration is more effective in prolonged B cell depletion.
Subjects were randomized to a double-blind infusion of either dexmedetomidine (dose ranges from 0.15 to 1.5 mcg/kg/h) or lorazepam (dose ranges from 1 mg/h to 10 mg/h).
The 9 500-patient EARLY ACS trial, 48 which was due to complete in July 2008, evaluates the utility of early eptifibatide administered as a double bolus plus infusion compared with initial placebo therapy with provisional eptifibatide begun just before PCI in patients with non-ST segment elevation ACS in whom an invasive approach is planned no sooner than the next calendar day.
In 13 of 30 patients, Ab to pegloticase that recognize PEG rather than the uricase protein caused the rapid elimination of pegloticase from plasma, associated with loss of efficacy and a doubled risk of infusion reactions.
GIR showed no significant increase during the infusion of 0.5 units/h (from 0.1 ± 1.0 to 0.3 ± 2.5 mg · kg−1 · min−1; NS); however, with a doubling of the infusion rate to 1.0 units/h (to 1.7 ± 2.5 mg · kg−1 · min−1; P < 0.001) and again to 2.0 units/h (to 3.8 ± 3.5 mg · kg−1 · min−1; P < 0.02), such an increase was registered (Fig. 1 D).
Finally – phew! – strain this infusion through a double layer of muslin into a clean bowl.
Patients randomly assigned to gastrazole received gastrazole at 500 mg day−1 dissolved in saline/ethanol administered as a continuous infusion via a double lumen central venous Hickman catheter.
Matthay et al. demonstrated the feasibility without significant toxicity of high-dose (up to a cumulative dose of 36 mCi/kg), rapid-sequence, double-infusion I-MIBG with stem cell support in patients with refractory or relapsed disease [ 8].
Furthermore, SAHZU has required that two licensed health care professionals must perform a "double check" prior to administering intravenous infusions of insulin, by implementing a standardized independent double-check process, since January 2013.
