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In the present study, we evaluated protection efficacy and immune responses in layer chickens, which had been immunized with a double immunization in order to optimize the efficacy of the vaccine.
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It was shown that H5N1 WIV that was produced in Vero cells did not require the addition of adjuvant and induced a cross-clade neutralizing antibody response after double immunization with a 7.5 15 µg dose [4].
Clinical trials that have been undertaken with conventional inactivated vaccines that were made from H5N1 viruses indicated that a high dose (up to 90 µg) and double immunization might be essential for an efficient immune response in humans [1] [4].
Furthermore, double immunization with the JOL916-JOL1229 may trigger elevated levels of immune responses to optimize the protection efficacy against FT infection in hens.
In the vaccine groups, single and double immunization equally brought the challenge virus to undetectable levels in the nasal washings at any time point after the challenge.
As in the previous study, serum antibody HAI or MNA titers to the heterologous IND05 strain were detected only after double immunization (results not shown).
The distribution of mosquito nets continued to expand, Child Health Days more than doubled immunization coverage in targeted locations, and the country remains polio free.
Following immunization, a double affinity purification strategy yielded a highly specific H2AK119ub1 antibody that recognizes native H2AK119ub and functions in ChIP.
To determine whether bystander tolerization occurred in LF-treated DC-induced immune suppression, we used a 'double immunization' system, in which mice were immunized with CII-pulsed DC alone with an immunization with KLH.
We report the use of a thermoresponsive gel (TRG) combined with a double mutant of a bacterial heat-labile toxin (dmLT) for sublingual immunization with a trivalent inactivated poliovirus vaccine (IPV) in mice.
A double.
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