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Rather than using a dose scale such as parts per million or milligram/kilogram/day in these cases, dose-response models can directly incorporate the impact of defense mechanisms by using a dose scale that corresponds to the number of invaders that break through the defenders and become free to do their damage.
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On a log dose scale, using a dilution factor of 1.47 corresponds to steps of log(1.47) = 0.38 each.
The largest deviations from the recommended dose occur on the higher side of the dose scale.
In discussing the results of Figure 1, I have concentrated on the dose scale.
Independent variables were standardized except for dose (scale unit = 6 visits) and self-care (scale unit = 1 on a 1 3 scale).
Independent variables were standardized except for dose (scale unit = 6 visits) and time (scale unit = 1 week).
To achieve optimum scaling, one has to stretch the dose scale by another factor 22 (= 4.7); that is, one has to use the particle number as a dose metric, as illustrated in Figure 3D.
These are −5, −1, 1 and 5 on the log dose scale (see also Table 1), corresponding to original dose levels of 0.007, 0.37, 2.72 and 148.4 units.
The calculation is simplified by the preceding assumption that the underlying continuous dose response relationships are "monotonic and parallel on a log-dose scale across species and across individuals within a species".
In the effect range of interest, the continuous dose response relationships are monotonic and parallel on a log-dose scale across species and across individuals within a species, so that the values (distributions) for any adjustments, variability, or uncertainties are independent of the selected critical effect size M*.
This relationship is approximately exponential or linear on a log-dose scale.
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CEO of Professional Science Editing for Scientists @ prosciediting.com