Sentence examples for a dose determination from inspiring English sources
For in vivo fluorescence imaging, 108 nmol/kg QE or 54 nmol/kg bivQ probe was injected intravenously (i.v ., according to the results of a dose determination experiment, which was set up to identify the optimal relation between sensitivity and contrast (Additional file 1).
Fifty-nine per cent of the patients anticipated that they might suffer severe or life-threatening side-effects if they participated in the phase I trial, and 43% were able to indicate accurately the purpose of the phase I trial as a dose determination study.
To determine a low oseltamivir dose exhibiting PK linearity, a pilot low dose determination investigation (n = 4) was performed using a single administration dose-escalation study.
It compared a medication containing 20 mg dronabinol (MarinolR), and 2 hemp milk decoction containing either a medium (15.8 mg average dose determination) or a high dose of THC (45.7 mg) with matched placebos.
Data from the acute toxicity study may (a) serve as the basis for classification and labelling; (b) provide initial information on the mode of toxic action of a substance; (c) help arrive at a dose of a new compound; (d) help in dose determination in animal studies; and (e) help determine LD50 values that provide many indices of potential types of drug activity [ 5].
Objective evaluation of botulinum toxin A (BTX-A) dosing by determination of the statistical relationship between injection amount and duration of side effects and normal voice in adductor spasmodic dysphonia (SD) patients.
In order to address this question, a clinical trial for optimal dose determination has been designed and is being conducted (FOILED study: ClinicalTrials.gov NCT01146821).
There is only one published pediatric study on dose determination involving a small group of 12 pediatric and juvenile patients (median age, 15 years) with invasive fungal infections; the therapeutic dose of posaconazole in 11 of 12 patients was 800 mg/day in divided doses with a median posaconazole through level of 579 ng/mL (range, 85.3 - 2891 ng/mL; mean, 776 ng/mL) [ 25].
Tocilizumab was infused in principle every four weeks at a dose of 8 mg/kg, a rate based on our previous dose determination studies [ 26].
This necessitates a frequent recalibration of the remaining dose (determination of activity per unit volume) and careful planning with respect to patient scheduling.
Again this is not so much of an issue as long as each dose determination method or approach is clearly detailed when presenting the paired biological data.
