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Patients currently receiving a statin who developed new-onset myalgias in ≥2 extremities within 60 days of initiation or a dosage increase were eligible.
One nurse coordinator listed in the report — conducted by investigators at the Office of the Inspector General (OIG) for the U.S. Department of Health and Human Services — questioned why a 6-year-old boy in foster care was prescribed four psychotropic drugs, especially since a dosage increase in one of the drugs negated the need for another medication he was on.
Persistent postprandial hyperglycemia led to a dosage increase.
For example, duplicate genes are preserved in the genome to achieve a dosage increase [ 14] or daughter genes both perform part of the ancestral function [ 15] (subfunctionalization).
For example, if patients fail fluconazole 200 mg/day, a dosage increase to 400 800 mg/day will frequently produce a clinical response for a period of time.
Vasoactive therapy was defined as an initiation or a dosage increase of dobutamine, dopamine, epinephrine, norepinephrine, phenylephrine or vasopressin during the HE.
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These features imply a low level of functional differentiation and possibly an mRNA dosage increase as an explanation for the retention of both duplicates in CRPs, although new provocative evidence suggests more functional divergence than expected [ 45].
A gene dosage increase driven by antibiotic stress in pathway assembly efficiently enhanced lovastatin production from methanol in P. pastoris.
PD patients in our study tolerated a levodopa dosage increase to above the 800 mg threshold, though there was an expected modest increase in dyskinesia duration, but not disability with escalation of dosages in the between-group scenario.
Moreover, due to a lack of dosage increase in the event of insufficient response without toxicity (a protocol deviation), some patients may not have benefited from an optimal masitinib dose with a consequent reduction in efficacy results.
A two-step dosage increase was used with both placebo and lixisenatide (10 μg for 1 week, 15 μg for 1 week, and then 20-μg maintenance dosage if tolerated), with injections self-administered by participants ≤1 h before breakfast.
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