The Lpa gene encodes an 80 kDa protein with an N-terminal amidase domain featuring a characteristic Ser-Ser-Lys catalytic triad and a C-terminal domain of unknown function [9].
As a MerR-like transcription factor, MlrA has an N-terminal DNA-binding domain featuring a helix-turn-helix motif, followed by a coiled-coil linker and a C-terminal putative ligand-binding domain (Brown et al, 2003).
Membrane targeting of stomatins is mediated by a 20 amino-acid amino (N -terminal membraN -terminaln domembraneturinsertionservedomainine (Kadurin et al, 2009).
MMPs have a similar domain structure that includes a prepeptide for secretion, a propeptide to maintain latency, and a catalytic domain, featured by the signature sequence HEFGHXXH, for substrate cleavage.
As represented by the v-Src SH2 domain, the structure of an SH2 domain features two α-helices (αA and αB) sandwiching a β-sheet consisting of seven anti-parallel strands (βA-βG) [ 38, 39].
There are 16 CNGC genes in rice, which were probably expanded through chromosomal segmentation and tandem duplications and comprise a PBC and a "hinge" region in the CNBD domain, featured by a stringent motif.
(61) In eukaryotes, this domain features a calcium ion-binding paired EF hand structure and a distal calmodulin-binding motif.
"In particular, we created a set of frequency domain features specific to cars," Jiang explains.
The domain features a spacious aromatic cage, ideally suited to accommodate methyl arginine residues.
DOI: http://dx.doi.org/10.7554/eLife.03145.013 Interestingly, the membrane domain features an additional helix, Iα, which lies parallel to the membrane, on the cytoplasmic side.
The goal of this is to create a mapping of the source domain features to the target domain features with the shared labels acting as the bridge.
