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A synthetic chaperone consisting of the granzyme B ER signal peptide and a domain encompassing putative N-linked glycosylation sites in granzyme B is insufficient for payload transfer to target cells, whereas full-length granzyme B is sufficient for payload delivery.
The Nkx2.1 Cre line allowed recombination in a domain encompassing the vDi dbx1-expressing population (Fig. S3A, B).
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The readout for this technique is to simply identify any alteration in trypsin resistant fragments by Western blot analysis using an antibody to a luminal domain encompassing a trypsin resistant epitope.
They show that the likely causal variants at this locus modulate expression of a chromosomal domain encompassing PLAG1 and several other genes.
Vpu, a membrane protein from human immunodeficiency virus-1, folds into two distinct structural domains with different biological activities: a transmembrane (TM) helical domain involved in the budding of new virions from infected cells, and a cytoplasmic domain encompassing two amphipathic helices, which is implicated in CD4 degradation.
Functional analysis of I-1 in a Saccharomyces cerevisiae strain dependent on human I-1 for viability established that a novel domain encompassing amino acids 77-110 is necessary for PP1 inhibition in yeast.
CXCL12γ is formed by a core domain encompassing the 68 amino-acids of the major CXCL12α isoform shared with all CXCL12 proteins, which is extended by a carboxy-terminal (C-ter) domain.
(F, G ) In older blastoderm stages cact3 is expressed in a broad domain encompassing 60 80% of the egg circumference.
In addition, variants modulating the expression of a chromosome domain encompassing PLAG1 influence stature in cattle [ 39].
These results were validated by studying a Tau domain encompassing aa 165 to 245 (Tau-F5) (Fig. 1g, h, and Additional file 4).
Using a library of chimaeric RyR3 RyR1 and RyR1 RyR3 receptors expressed in dyspedic myotubes, we show that the ability of the RyR1 and RyR3 to confer isoform-specific [Ca2+]rest regulation can be traced to a small domain encompassing amino acids 3770 4007 of the C-terminal region of RyR1 (amino acids 3620 3859 of RyR3), which we referred to as the CLR (Ca2+ leak regulatory) region.
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