By definition, normal stem cells give rise to the cellular components of an organ by asymmetric division mediating their self-renewal and differentiation potential [ 6].
Similarly, a critical effect on cell division mediated by WEE1 was observed in hESC [49] where miR-195 expression in Dicer-knockdown cells rescued cell cycle kinetics by directly targeting WEE1 3'UTR.
The increase in division mediated by IL-2 and IL-15 plus IL-21 was matched by an increase in total cell number of NK cells.
Adherbal fled to Rome for assistance, and initially Rome mediated a division of the country between the two brothers.
Mitochondrial division is mediated by a dynamin-related protein, Dnm1 (in yeast)/Drp1 (in mammals) (Lackner and Nunnari, 2009), which self-assembles in a regulated manner on the surface of the mitochondrial outer membrane into helices that mediate mitochondrial scission (Ingerman et al., 2005; Mears et al., 2011).
It is common for XP/CS and TTD patients to display neurological abnormalities and developmental defects (Kraemer et al., 2007; Lehmann et al., 2011), suggesting a possible link between these phenotypes and the regulation of cell division timing mediated by Xpd.
In Euryarchaeota and Korarchaeota (as well as most bacteria), cell division is mediated by FtsZ proteins, which are homologous to tubulin, the building block of the microtubule cytoskeleton in eukaryotes [43] [44].
10.7554/eLife.02131.011 Figure 5. Trafficking to the plane of cell division is mediated by BIG1 – BIG1.
Interestingly, peroxisomes and mitochondria share key components of their division machinery: DLP1, a large GTPase mediating final membrane scission is recruited to both organelles via its membrane receptors Fis1 and Mff, which as well localize to peroxisomes and mitochondria, - (Fig. 1).
FGFR2 is a receptor tyrosine kinase mediating cell division, growth and differentiation signaling.
These divisions are mediated by meiotic spindles that are asymmetrically positioned against the oocyte cortex with the pole-to-pole axis of the spindle perpendicular to the cortex.
