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The maintenance TPM-IR dosage of 200 400 mg/day is administered as a divided dose.
For this reason a new schedule using a divided dose in order to maintain the blood level of ABT-751 has been formulated.
As prolactin level remained elevated after a further 3 months of treatment, cabergoline dose was increased to 5 mg in a divided dose twice a week.
This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6 8 weeks.
Recent phases I and II trials of chemoradiotherapy with a combination of gemcitabine and cisplatin in locally advanced pancreatic cancer patients used a divided dose of cisplatin (Brunner et al, 2003; Wilkowski et al, 2004; Haddock et al, 2007).
SOF was administered at 400 mg once daily and RBV dose was based on body weight (1000 mg per day for <75 kg and 1200 mg per day for ≥75 kg in a divided dose) in all patients.
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12 Moreover, Shale and Riley 10 reported that approximately only half of patients adhere to the prescribed dosing schedule especially under a divided dosing regimen (three times daily), resulting in a median amount of medication administered of approximately 70% of the dose.
The 138 patients randomized in study 81-0045 to receive G-GR as an asymmetrically divided dose (1,200 mg PM/600 mg AM) were not included in the dataset used for the current analyses.
MMX mesalazine 2.4 g/day administered as a single or divided dose demonstrated a good safety profile, was well tolerated and was effective as maintenance treatment.
This study (SPD476-303 (clinical trial registry web address as of 21 July 2007: http://www.clinicaltrial.gov/ct/show/NCT00151944?order = 1)) aimed to investigate and compare the long-term safety and efficacy of maintenance MMX mesalazine 2.4 g/day, given either as a once-daily or a twice-daily divided dose in patients with UC in remission.
20 The maximum recommended dose of sitagliptin is 100 mg daily in a single or divided dose.
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