This view has evolved through studies correlating EGFR expression with disease progression in multiple tumour types (Sainsbury et al, 1987; Salomon et al, 1995; Maurizi et al, 1996; Dong et al, 1998) and evidence that EGFR-inhibition can influence a diverse range of pathways, including those involved in proliferation, reduced apoptosis, angiogenesis and invasion (Woodburn, 1999).
In constructing these graphical models which encompass a diverse range of biological pathways and concepts, we found it necessary to refine the Edinburgh Pathway Notation (EPN) scheme as previously proposed [ 28, 30].
Furthermore, traceable proteins belonged to a diverse range of signaling pathways in developmental processes, for example, for calcium, MAPK (mitogen-activated protein kinases), WNT (signaling pathway first discovered in Drosophila melanogaster), and Jak-STAT (Janus kinase-signal transducer and activator of transcription).
The ubiquitin (Ub -binding p62 scaffold protein (encoded by the SQSTM1 gene) regUb -bindingverse range of signalling p62hwayscaffoldg to activation of the nuclear factor kaproteinNF-κB) family of transcription factors and is an important rencodedr of macroautophagy.
Analysis of these mutations has revealed that control of transcriptional pausing is critical for a diverse range of biological pathways essential for animal development and survival.
They regulate a diverse range of biochemical pathways and biological functions and are often indispensable signal integrators in a living system.
BARD1 interacts with the RING domain of BRCA1 and coordinates a diverse range of cellular pathways to maintain genomic stability, including DNA damage repair.
Because NRDc modulates a diverse range of signalling pathways, we postulated that it might be involved in the development of human cancers such as gastric cancer.
Our inference that proteins affecting a diverse range of molecular pathways are also more likely to experience adaptive evolution is consistent with this hypothesis.
As our pathway mapping efforts have continued to develop and been driven by our interest in modeling a diverse range of biological pathways and concepts, we found it necessary to further refine the EPN scheme.
Mutations recovered in genes encoding elongation factors have revealed their involvement in a diverse range of biological pathways including the pathogenesis of numerous cancers, embryonic patterning, haematopoiesis, and also neuronal development, migration and degeneration.
