Sentence examples for a diverse compound from inspiring English sources

More specifically, classification of a diverse compound set deeply influences the validation and the predictive power of prediction model for the designing of novel compounds.

For a diverse compound set, the affinity patterns correctly classify inhibitors as having type I or type II binding modes, and we show that juxtamembrane domain docking can have dramatic negative effects on inhibitor affinity.

In order to identify histone demethylase inhibitor templates, we applied this assay for high-throughput screening of a diverse compound library, comprising the Molecular Libraries Small Molecule Repository (MLSMR) and additional collections, against the 2OG-dependent histone demethylase JMJD2E (KDM4E).

With the growth of the additional chemical classes of compounds to be screened, a more robust model may be developed with the availability of biologically interesting small molecules from a diverse compound library.

The observation of three nontrivial chemotype modifications underscores the ability of fragment-independent numerical descriptions to map the chemical structure of a diverse compound library into a numerical fingerprint.

To discover novel cell cycle phase specific inhibitors, human HeLa cancer cells were plated into 384-well plates and a diverse compound library (79 827 small molecules) encompassing broad chemical space was used to place one compound per well at 10  μM final concentration.

Xie and Chen (2008) presented a strategy to select a diverse compounds subset from the PubChem database.

A molecular docking-based virtual screening task can be conducted starting with a target protein and a large, diverse compound library.

For gene transactivation, the functional activity of the agonists, a corresponding model for a similarly diverse compound set is of somewhat lower statistical quality.

Each of their Hexes contains a dense, diverse compound of samples, congealing in a startlingly authentic rendition of psych rock.

A weak antagonist of WDR5 binding to WIN-peptide was identified [ 110] using a fluorescence polarization assay (FP) through screening of a 20,000 diverse compound set and this was optimized to give OICR-9429 and an inactive control, OICR-0547 [ 111].