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In conclusion, we have shown that there is a divergent response to TGFβ in cells from BE adenocarcinoma.
The CD44s-Fusion cells showed a divergent response, with a minimal but significant increase in hyaluronan binding but no increase in osteopontin binding.
Overall, the RRHO analysis thus shows that the observed divergent signalling patterns of mutant and wild-type proteins also translate into a divergent response.
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Analysis of the expression of cytokines implicated in the polarization toward a Th1 or Th2 phenotype, revealed a partially divergent response in the two strains of mice.
However, a more divergent response in plasma lactate and Hx levels indicate an elevated metabolic stress and altered muscle metabolism with HIIE.
This higher genetic similarity may potentially explain the higher conservation observed between GP and MT. More than 50% of the genes up-regulated or down-regulated in GP are also similarly regulated in MT. Our analyses indicate an unexpectedly divergent response of barley and rice to salt stress.
Gyroscopic conservative dynamical systems may exhibit flutter instability that leads to a pair of complex conjugate eigenvalues, one of which has a positive real part and thus leads to a divergent free response of the system.
For the purposes of this study, we shall define the biotype as an intraspecific classification, segregating individuals by a divergent phenotypic response to an ecological variable.
These results lead to the following questions: (1) What are the differences between the 'toxic' and 'nontoxic' types of Hb that could explain such a divergent biologic response?
We found that androgens generated a divergent UPR response in which the IRE1α arm was activated, whereas the PERK pathway was inhibited.
In summary, these results suggest that androgens induce a divergent UPR response to promote prostate cancer growth and that targeting IRE1α signaling may have utility as a novel therapeutic approach in prostate cancer.
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