Patient acceptance remains the main limiting factor to wide distribution of screening.
Meanwhile, the distribution of screening positive for depression did not show any differences between the two groups.
We calculated the distribution of screening appointments according to birth month of those invited to screening and used the χ test for statistical significance.
The Ministry of Health provided information on direct costs of the screening program at the national level, considering costs for mobilization and mass media advertising, purchase and distribution of screening test kits, training of healthcare workers, and overall screening program management.
Furthermore, the possibility of confounding by additional factors, including factors that are of specific concern in screening studies, such as different temporal distribution of screening between cases and controls, or the administering of other screening tests that may have interfered with application of screening endoscopies has to be kept in mind.
To generate the results presented in the revised Figure 4, we therefore simulated 2000 trips made by a population of 50 infected travellers, which should sufficiently capture the distribution of screening outcomes.
The distribution of screening intervals is shown in Table 4, the mean interval for those screened prior to 1997 being 12.4 months compared to 24.1 months for those screened after 1997.
Studies that evaluate inherited genotype and tumor characteristics, natural history, or prognosis could benefit by reporting the distribution of screening practices and the stages or grades of tumors studied.
The algorithm corrects the maximum likelihood estimates of the parameters of the distribution of case screening test scores.
For more recent years of nation-wide screening, the National Evaluation Team for Breast Cancer Screening in The Netherlands found a more or less stable tumor size distribution of screen-detected cancers, as well as a stable rate of lymph node positive breast cancers [ 12].
