Defensins, a family of secreted antimicrobial cationic peptides with molecular weights of 4 5 kDa, have a distinctive sequence pattern of six to eight cysteine residues.
These features are likely to produce a distinctive sequence and expression pattern of Z chromosome comparing to that of X chromosome and autosomes.
Importantly, our analysis revealed that the distinctive sequence features of the SLC6A3 gene recognized by an array of regulatory mechanisms are evolutionally recent.
We first showed that the distinctive sequence specificities of H3K4me3 and H3 nucleosomes are consistent among different cell types.
Additionally, the distinctive sequence pattern of known MGST3 proteins, FNC [AIV]QR [AGS]H [AQ] [HQ]-x(2 Ex 2,3 P, was also observed in DvM 695 [ 26].
Using peptide combinatorial libraries, Thornberry and co-workers had previously identified the presence of distinctive sequence specificities governing protein cleavage of both caspase and granzyme B substrates [ 4].
Since recombination was lost at different time points, each affected region shows a distinctive level of sequence divergence between sex chromosomes from adjacent regions, manifested as a pattern of 'evolutionary strata' [ 5- 9].
Intrinsically disordered proteins possess distinctive sequence features, including paucity of hydrophobic residues and enrichment in hydrophilic residues, which allow them to be predicted with a rather good accuracy.
To further investigate FindMiRNA predictions we proceeded with two additional parallel analyses, the former based on comparative genomics (see later), and the latter on distinctive sequence and structural features of the hairpins.
Tandem duplications and deletions are among the easiest structural mutation class to recognize with short-read sequence data because of their distinctive sequence characteristics (supplementary fig. 1, Supplementary Material online).
