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The creative power of evolution arises from a distinctive interaction between chance and necessity, between random mutation and natural selection.
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A distinctive interaction can be measured either as high c, d or high c and low s.
There may be two alternative specifications of a distinctive interaction in any pharmacological space.
The yeast two-hybrid matrix method involved a subset of 9 F-box and 30 OSK proteins and uncovered selective and distinctive interactions between the OSK proteins.
Distinctive interactions occur between drugs having high c and above (below) average d (s).
Most distinctive interactions occur between vitamins and medicines curing ailments of classes such as central nervous system or dermatological in nature.
Each hybrid thus forms a distinctive region of interaction between the two RNAs.
Test 6 establishes the advantage of d as a potential filter of distinctive interactions.
One is a methodological contribution as we provide a mathematical basis for identifying distinctive interactions, commonly studied as activity cliffs in literature.
Test 6 gives the significance of variation as a refined filter of rare distinctive interactions.
The methods provide a basis for practitioners and pharmacologists to identify distinctive interactions and the region of chemical space that they are probable to be observed in.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com