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Although we cannot exclude the possibility that DAZL can block the association of miRNA with target mRNAs, the induction of polyadenylation by DAZL strongly suggests that DAZL relieves miRNA-mediated repression in a distinct mode from DND.
The existence of this conformation is supported by structural studies which have shown that the DLG motif binds to Keap1 in a distinct mode from the ETGE motif, with "fast on fast off" kinetics (Fukutomi et al., 2014).
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In fact, the microtubule stabiliser paclitaxel, even with a distinct mode of action from eribulin, decreased Smad2 phosphorylation in gastric cancer (Tsukada et al, 2013).
Whether this is an indication that arixanthomycin A (1) has a distinct mode of action from other pentangular polyphenols or that the sugar is needed to improve the bioavailability of 1 in light of the new carboxylate remains to be determined.
Their results suggested that sRNA provides a distinct mode of gene regulation from that of protein-mediated one.
A comprehensive analysis of the structurally known ABC transporters shows a high degree of conservation of the identified 3-motif coupling elements only in the subfamily of small ABC importers, suggesting a distinct mode of NBD-TMD coupling from the other two major ABC transporter folds, namely large ABC importers and ABC exporters.
However, the average size of the ToLFP signal was the largest in nuc-1 embryos, suggesting a distinct mode of action of NUC-1 from that of CRN-6 or CRN-7.
Therefore, moving the cells towards the light source and away from it in a distinct mode by convective mass transfer is the method of choice to cope with these inhibitive effects.
LukAB stands out from the family of staphylococcal leukocidins, having a low sequence homology with other leukocidins and a distinct mode of action4.
We are a third thing, a distinct mode of transportation, requiring different practices and different rules.
As the malacidins are structurally distinct from other calcium-dependent antibiotics, we sought to determine whether they function by one of these known mechanisms or a third distinct mode of action.
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