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A distinct linkage disequilibrium occurs with HLA DR or DQ alleles.
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A total of 11 distinct linkage groups were identified, which corresponds to the haploid number of chromosomes in C. japonica.
Markers with more than 5 recombinants were not grouped together and are presented as distinct linkage groups for a particular chromosome.
These SNPs are spread across a 1.3-Mb region and constitute four distinct linkage disequilibrium (LD) blocks, two of which contain SLC22A11 and SLC22A12[ 2].
A total of 7 contigs had been identified that mapped on 7 distinct linkage groups.
We found 5 distinct linkage groups for F252 and two for MBS (Fig. 4 a and b).
To account for distinct linkage disequilibrium patterns in Hispanics and further assess generalization of genetic effects at each locus, we interrogated the evidence for association at the 47 surrounding loci within 1 Mb region of the index or proxy SNP.
The discordant results of MHC/ageing association studies might be due to distinct linkage in different cohorts or to other interacting, genetic or environmental factors or to the heterogeneity of ageing.
A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns.
SNPs genotyped in these patients show distinct linkage disequilibrium (LD) relationships in European and African descended populations [16].
This is likely an artifact of low diversity given that these loci have been mapped to distinct linkage groups in the related warbler A. arundinaceus (B. Hansson pers. comm).
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