Cohesin is one of the most important cofactors of CTCF, and exhibits distinct functionalities in the presence or absence of CTCF [ 32].
If the different conformers have distinct functionality at a site that is distinct from the site of perturbation, allosteric behaviour is observed (12, 40, 41, 50, 51).
Paralogous HOX genes have many similarities in function but can also display distinct functionality [ 12, 13].
Each component serves its distinct functionality and is implemented at a different stage in the biomarker discovery process.
Since ATM may exhibit distinct functionality because of its different localization in proliferating and differentiated SH-SY5Y cells, we compared the response of ATM to DNA damage and growth factor signaling in differentiated and undifferentiated SH-SY5Y cells.
Firstly, these biopolymers can occur in multiple conformations that can have distinct functionality, with the predominant conformer depending on the molecule's environment, for instance, the presence of a particular binding partner (12 16).
The fabrication of materials that require highly heterogeneous nanoscale structures, for example, where the material requires distinct functionality at different locations, is still a significant challenge.
Thus the clustering method used here appears to have provided a useful separation of orthologous gene groups into subsets of distinct functionality.
Many paralogous proteins acquire distinct functionality by gaining or losing SLiMs [ 38, 39] that result in differential regulation [ 36, 40] or subfunctionalisation [ 41, 42] (Fig. 2d- e).
In general, our data correlate well with the distinct functionality of the full-length receptor tyrosine kinases and their respective intracellular domain (ICD) proteolytic fragments.
