In a second dissemination study, inoculated mice were subjected to ear biopsy for up to 7 weeks as described previously [17].
Personal contact with citizens seemed infeasible for a substantial portion of organizations, which is consistent with findings of a smaller scale dissemination study of an evidence-based PA promotion program for the elderly in community organizations [ 30].
Briefly, this dissemination study employed a pre- and post-test evaluation design, and comprised two cohorts: the main GHS coaching cohort (with data collected by GHS coaches at baseline and 6-months) and the independent sub-sample coaching cohort, randomly drawn from the main GHS coaching cohort (with 12-months data collected by an independent evaluator).
This dissemination study examined the effectiveness of therapist-assisted Internet-delivered Cognitive Behavior Therapy (ICBT) when offered in clinical practice.
The campaign image of all organizations continuing '10,000 Steps' was different from the campaign image promoted during the prior dissemination study.
A systematic review of dissemination studies concluded that more active, multimodal dissemination and implementation strategies are more likely to be effective [ 9].
To address this gap, two hypothetical dissemination studies are presented: a quasi-experimental study of local health agencies (Scenario 1) and a group-randomized trial of clinical practices (Scenario 2).
Escherichia coli SIG-1, a clinical strain, was the microorganism inoculated in the neutropenic mouse thigh infection model for all experiments with a microbiological endpoint (24 hours duration), and Pseudomonas aeruginosa GRP-0019, a fully-susceptible catheter isolate, for dissemination studies in the survival model (4 days long).
Interventions are not well disseminated or integrated into clinical care [ 13, 34], though some dissemination studies are underway [ 34, 35].
Secondly, an estimate of recovery was made by identifying the proportion of participants in each group who demonstrated a significant reduction in their symptoms (defined here, as a reduction of 50% of pre-treatment PHQ-9 scores) as described in recent dissemination studies [45].
