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A role for another myeloid-derived cell type, the neutrophils, in determining the site of metastasis was suggested in a dissemination model in zebrafish.
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A better dissemination model should recognize and utilize interactions as a way to encourage change, especially when trying to reach the mainstream adopters who may not seek out information about a reform.
Many researchers such as Bailis et al.[13] and Barnes et al.[6] acknowledge that although the market-based approach can achieve a sustainable dissemination model, it may filter out the poorer section of rural community.
In a peritoneal dissemination model, NEK2A siRNA-treated mice showed statistically longer survival periods in comparison with those of the control siRNA treated mice [ 46].
KATO-III, SNU-5, SNU-16, and SNU-620 are often used as a peritoneal dissemination model in nude mice because of their reportedly high potential for peritoneal dissemination.
We present a modified dissemination model developed with the goals of: 1) broadening the dissemination experience to more students doing a range of class-based research and 2) increasing the impact of student generated findings by publishing them directly to an appropriate scientific user group.
Taken together, our results indicate that NF-κB decoy transfer by Man-PEG bubble lipoplexes and US exposure into TAMs is an effective method to inhibit MA progression in a mouse peritoneal dissemination model of EAC.
In conclusion, we succeeded in efficiently delivering a NF-κB decoy into TAMs by Man-PEG bubble lipoplexes and US exposure in a mouse peritoneal dissemination model of EAC.
Here, we developed targeted transfer of a NF-κB decoy into TAMs by ultrasound (US -responsive, mannose-modified liposome/NF-κB decoy complexes (Man-PEG bUS -responsivees) in a mouse peritoneal dissemination model of Ehrlich ascites carcinoma.
We also showed that a CD47 blocking antibody enhanced the phagocytosis of gastric cancer cells by macrophages and significantly improved the survival rate in an intraperitoneal cancer dissemination model.
The overall method is to use a "train-the-trainer" dissemination model.
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