The phrase "a disrupts" is not correct in written English.
It appears to be a grammatical error, as "a" should not precede a verb like "disrupts."
Example: "The sudden change in policy disrupts the workflow."
Alternatives: "causes disruption" or "creates a disturbance."
To clarify whether the potential pathogenic variation in the exon intron boundary junction, c.906 +3 G > A, disrupts splicing efficacy of HTRA2, we performed quantitative real-time PCR (q-PCR) and reverse transcription PCR (RT-PCR) analyses to check the gene expression of HTRA2 in one of our EOPD patient, labeled as Y63, and seven age-/gender-matched control subjects.
To further support the finding that Compound A disrupts the constitutive interaction between ERRα and nuclear coactivators, we also performed ChIP assays after MCF-7 cells were treated with vehicle (DMSO) or 5 uM Compound A for 24 and 48 hours.
Apicularen A disrupts microtubule networks by inhibiting tubulin synthesis [ 5].
Brefeldin A disrupts the structure and the function of Golgi apparatus and interferes with cell membrane traffic [ 35, 36].
But withefrin A disrupts majority of these hydrophobic interactions by placing itself in between the binding chains, As depicted in Figure 6 for Cluster 1, WA itself starts forming strong intermolecular interactions with these critical residues.
Although our findings do not directly illustrate the necessity of nuclear lamina breakdown in reorganization of the cytoskeleton, other groups have shown that over-expression of wild-type or mutant lamin A disrupts fat cell differentiation and lipid accumulation, whereas complete lack of lamin A conversely promotes adipogenesis (Akter et al. 2009; Boguslavsky et al. 2006; Capanni et al. 2005).
Thus, it is possible that the substitution observed in GC-A disrupts the assembly of a functional dimer, consistent with the observed loss of catalytic activity.
Brefeldin-A disrupts translocation of cellular material in minutes and this is in keeping with our observations of altered LP and glycocalyx depth over this period.
(C) A 45 min treatment with extracellular latrunculin-A disrupted the synaptic F-actin cages.
A T. reesei strain was constructed using gene disruption techniques that contained a disrupted cre2 gene.
