In contrast to the disrupted organelles noted above in BV2 microglia, mitochondria appeared ultrastructurally normal in the N27 neurons, in spite of their close proximity to P25 aggregates.
"You can modify behavior later, but you can't rewire disrupted brain circuits," notes Jack P. Shonkoff, a Harvard pediatrician who has been a leader in this field.
Today, for instance, Microsoft might take comfort from the fact that Excel has more features than any other spreadsheet, whereas a potential disrupter might note that people are driven to despair when trying to transfer files from an old to a new computer.Thus, technology has historically advanced in waves of disruption.
More generally, we noted that peptides designed to specifically disrupt an interaction disrupted only the targeted and expected interactions in Astro#40 and U87 cells (2: Figure S2).
Previous research has noted disrupted patterns of neural activation during emotion, processing in individuals with autism spectrum disorders (ASD).
It is most evident in "What's Opera, Doc?," but it is also central to "Rabbit of Seville" (1950), a send-up of Rossini's barber; "Long-Haired Hare" (1949), in which a pompous tenor is tortured by Bugs, and "High Note" (1960), in which musical symbols on a staff play the "Blue Danube" waltz and are disrupted by an inebriated quarter note.
TechCrunch went to China to stage a Disrupt in 2011, and we should note that this Fall, we will do a small event in Beijing, and next year we will bring a full-on Disrupt back to China.
Of note, an overnight incubation disrupted the monolayer not only of the treated cultures but also of the negative controls, which supports the importance to perform time-controlled experiments.
"Plenty of disruptive technologies never actually disrupt a market," he noted.
Disrupted sleep, the authors note, can cause problems with the immune system, infection resistance and wound healing — all of obvious importance to patients recovering from illness or injury.
This isn't all that surprising given the level of innovation activity in these sectors, but directors operating in similarly disrupted sectors should take note.
