The nonuniform case involving discrete pools of activity showed the dose distribution being confined largely to the regions surrounding the delivery ports with significant regions between these ports receiving very little dose.
The existence of functionally discrete pools of S1P1 receptors has been shown in murine embryonic fibroblasts, airway smooth muscle cells and transfected HEK293 cells.
In the spinal cord, for example, identified progenitor cells generate discrete pools of interneurons, which in turn have defined roles in producing functional circuits (Grillner and Jessell, 2009).
Because melanocytes derive from small discrete pools of neural crest cells that undergo circuitous migrations, depending on their final destination, the key expectation derived from this literature is that pigmentation should be depleted in domesticated species, but not that its pattern should take any specific form.
Moreover, another PtdIns(4,5) P2-generating enzyme, PIPKIIβ, targets to nuclear speckles and also does not associate with Star-PAP [ 22], which supports the hypothesis that there are several discrete pools of nuclear PtdIns(4,5) P2 that are generated by PIPKIγ_i4, PIPKIα or PIPKIIβ.
This apparent paradox may be explained on the basis that either (i) insulin targets a discrete subcellular pool of GSK3 that is not directly linked to regulation of the mTORC1 complex, and/or (ii) the extent to which the hormone inhibits GSK3 is insufficient to impact upon mTOR activity.
The coastal towns of Monopoli and Savelletri di Fasano lie at the center of this activity, and Monopoli presents a tidy, decidedly upscale emblem of it: La Peschiera, a five-star hotel that, despite its waterfront location, has seven discrete pools — some of them, admittedly, tiny ones — for just 11 rooms.
Once a mutation was revealed, the eight-fold pool (samples: 1 8) was remixed into eight discrete pools consisting of two individuals each (samples: 1&2, 3&4, 5&6, 7&8, 1&3, 2&4, 5&7, and 6&8).
Materials and methods: The radioisotope source distribution was modeled for two configurations within the vessel wall: (1) uniform to a depth of 0.5 mm and (2) confined to discrete pools surrounding the delivery injection ports.
A key finding from this study was the determination that Zn accumulates in large discrete pools associated with and/or proximal to the nucleus in mammary cells of lactating mice.
