This combined information can be very valuable for a directed screening of microsatellite markers linked to CCR in populations segregating for microfibril angle in an attempt to validate this QTL in different populations or Eucalyptus species.
To pursue the idea that small RNA might play a role in dosage compensation, we conducted a directed screen of RNAi pathways.
In conclusion, this study substantiates that gross gene abnormalities in PROS1 are relatively common in hereditary PS deficient patients and that MLPA is a useful tool for direct screening of CNVs in PROS1 point mutation-negative individuals.
Previously we showed, through direct screening of a combinatorial peptide library in a cancer patient, that the selective homing peptides localized non-randomly to specific organs [1]; we also identified a cyclic peptide (sequence CGRRAGGSC) targeting prostate vasculature and prostate cancer as an interleukin-11 (IL-11) mimic [1], [2].
More recent studies based on the direct screening of an unselected population in Northern Europe showed a prevalence of HeFH of 1 in 200, and by extrapolation, HoFH may affect up to 6 individuals per million (or 1 in 160,000 300,000) [ 5].
We investigated the suitability of surface plasmon resonance (SPR) for providing quantitative binding information from direct screening of a chemical library on protein tyrosine phosphatase 1b (PTP1b).
This was achieved by direct screening of a T. parva Muguga schizont cDNA library with CD8 T-cell lines.
We demonstrate for A. thaliana that this strategy opens the possibility of direct screening of a BAC library using pooled freezing stocks for PCR with high throughput, at low cost, and a minimum risk of false positive/negative results.
A fast and simple flow-through optosensor was designed and characterized for the direct screening of four tetracycline (TCC) antibiotics (tetracycline, oxytetracycline, chlortetracycline and doxycycline) in water and bovine milk samples.
Animal cells have been used for the direct screening of hypermutating antibodies [11], [12] and during antibody selection from a retroviral-antibody display library [13].
