Studies have shown that nuclear envelope fission (karyokinesis) in budding yeast depends on cytokinesis, but not distinguished whether this was a direct requirement, indirect, because of cell cycle arrest, or due to bud neck-localized proteins impacting both processes.
"That a direct requirement for most Americans to purchase any product or services seems an intrusive exercise of legislative power," Judge Silberman wrote, "surely explains why Congress has not used this authority before — but that seems to us a political judgment rather than a recognition of constitutional limitations".
Satellite cells formed in Pax7-null mice are rapidly depleted from muscle following birth [15] [17], but it is unknown whether this occurs as a result of defects acquired during development, or through a direct requirement for Pax7 postnatally.
Alternatively, the relationship between ept and Dome localization could indicate a direct requirement for ept in Dome endolysosomal trafficking in much the same way that ESCRT mutants block the vesicular movement and lysosomal turnover of the Notch receptor [4] [6], [47].
It is possible that it is a consequence of the loss of expression of regulatory genes during hindbrain segmentation, or there might be a direct requirement for Med12 function in proliferation or in the synthesis of components of the machinery that supports DNA replication and cell division.
Our results identify a direct requirement for ezrin in Src-induced VEGF-C expression in breast carcinoma cells.
The involvement of syntaxin-1/SNAP-25 acomplexesomplexes in docking suggests a direct requirement for SNAP-25 in docking, similar to syntaxin-1.
In addition to regulating mammary placode formation and ductal elongation, a direct requirement for Gata-3 in epithelial cell differentiation was demonstrated.
