The phrase "a direct modulation of" is correct and usable in written English.
It can be used in contexts related to changes or adjustments in a system, signal, or process, often in technical or scientific discussions.
Example: "The researchers observed a direct modulation of the signal frequency in response to the environmental changes."
Alternatives: "an immediate adjustment of" or "a straightforward alteration of".
Our work further reveals that ActivinB expression is mediated through a direct modulation of H3K27me3 marks on the Inhbb locus in Menin-KO cell lines.
At present various options are under consideration: (a) direct modulation of the transporter by specific inhibitors, (b) interference with the regulatory cascade of protein transcription, translation and function, and (c) encapsulation of substrates into delivery systems, which are able to by-pass p-glycoprotein.
Conclusion - The results of the present study suggest that the clinical efficacy of a short-lasting KD regimen in migraine can be primarily due to a general normalization of the interictal cortical dysfunction, and not to a direct modulation of the subcortical brainstem activation.
Therefore, decreased BDNF concentrations are unlikely to reflect a direct modulation of lymphocytic BDNF production in SSc.
Thus part of the stress signaling response in the brain is a direct modulation of the synapse itself by adrenal steroids.
The current findings provide the first evidence for a direct modulation of endogenous neural oscillations by transcranial alternating current stimulation of the human cortex.
Consistently, we observed TRPC3-dependent promotion of cyclic NCX activity in a voltage-clamp protocol, corroborating the principle of a rather direct modulation of NCX operation by the TRPC3 conductance.
These results suggest that while feedback mechanisms between protein abundance and transcript levels exist, the majority of the effects observed here for both hfq and smpB are a result of direct modulation of post-transcriptional events.
This suggests to us that some of the effects we detected in monocytes may be a combination of direct modulation of CTLA4 on monocytes as well as indirectly due to changes in cytokine levels upon CTLA4 blockade in neighboring T cells.
This evidence supports a lack of direct modulation of COMT on suicidal behavior.
Moreover, we have shown that in vitro, an absence of direct modulation of recombinant TRPM8 by oxaliplatin or its metabolites.
