Sentence examples for a direct marker from inspiring English sources

Genes including a direct marker or genes within one Mb in either direction of a marker (to minimize the possibility of recombination between marker and causal mutation) were regarded as adaptive variation whereas all other markers were regarded as neutral variation.

The change from A-lines to B-lines, which defines septic shock in the FALLS-protocol, can be considered as a direct marker of clinical volemia.

By combining the cell cycle length predicted by the model with measurements of total cell population and mitotic rate, this approach facilitates the quantification of exit from this compartment without the need for a direct marker of that event.

Lastly, we did not employ a direct marker for vitamin D among these study subjects.

At diagnosis, erythrophagocytosis (a direct marker for extravascular hemolysis, EVH) was enhanced in SMA compared to MM patients (5.0 arbitrary units (AU) (interquartile range (IR): 2.2 9.6) vs. 2.1 AU (IR: 1.3 3.9), p<0.01).

A caveat to these assays is that we cannot prove that LRRK2 is active in these cells without a direct marker of LRRK2 phosphorylation, although we were able to extract LRKK2 and measure autophosphorylation activity ex vivo.

To examine a more direct marker of tissue inflammation we quantified ICAM-1 as it will be expressed by the vascular endothelium where leukocytes will bind ICAM-1 on the endothelial surface and transmigrate across the vascular endothelial and into tissues during the inflammatory process [ 40, 41].

TREM-1 amplifies infection-induced inflammatory response signals primarily through the mediation of adapter protein DAP12 on the cell surface [ 47]. sTREM-1, as the soluble form of TREM-1, released by activated phagocytes, may be a more "direct" marker of infection.

Our results support the potential of white blood cells as a proxy tissue for studying insulin signaling and may lead to development of a minimally invasive and direct marker of insulin resistance.

These data may suggest that the presence of anti-JCV antibodies is not a direct surrogate marker for JCV exposure but rather a marker of increased viral burden in an individual due to either an ongoing infection or periodic reactivation of the virus from latency.

Native T1 mapping shows elevated T1 values, which is an early indicator and direct marker of cardiac amyloid [40].