The phrase "a direct impairment" is correct and usable in written English.
It can be used in contexts discussing health, functionality, or performance issues that affect an individual or system directly.
Example: "The injury resulted in a direct impairment of her ability to walk without assistance."
Alternatives: "a significant limitation" or "an immediate hindrance."
Nicolson & Fawcett [35] propose a direct impairment of balance and motor skills due to cerebellum impairment in dyslexia.
Possible mechanisms for the increase in bilirubin may be an AVP-mediated reduction in hepatic blood flow [ 98] or a direct impairment in hepato-cellular function.
Thus, our data suggest a mechanistic difference when comparing the consequences between eliminating adaptor cargo interactions with a direct impairment of motor functions.
Furthermore, the interactions between the NLS and Kpna1/Kpna6 were not affected by the W255G substitution, excluding the possibility of a direct impairment of the NLS Kpna1/Kpna6 interaction.
Mutations can cause a lack of function by direct impairment of protein activity, by a lack of protein expression or by its incorrect trafficking.
Gene knockouts might also contribute to a lethal embryo phenotype through direct impairment of placental function or development and, for this reason, any comprehensive screen to analyse recessive lethals should also include systematic assessment of placental structure (Adams et al., 2013).
10 Although these conditions do not cause a direct physical impairment, with the rare exception of ocular rosacea causing vision disturbances, there is a profound psychosocial impact.
To our surprise, although the total number of NeuN-positive neurons did not change under either SNL or SNL + L-AA treatment, the activation of neurons was suppressed by L-AA treatment, possibly via an indirect way other than L-AA's direct impairment to neurons.
PAG volume expansion may be the direct impairment evidence on the brain in EM, and could be considered as a diagnostic and evaluated imaging biomarker in migraine.
In EM patients, PAG volume showed no any correlation with the clinical variable, and this point indicated PAG volume expansion may be the direct impairment in EM and may be associated with pathological substrates [13].
The direct impairment of the proliferative and metabolic activity of osteoblasts is mediated by a number of different mechanisms.
