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For example, the positive or negative genetic interaction between two genes does not specify a direct functional relationship without additional information [18].
However, whether they have a direct functional relationship with the EEVS and MT-Ox genes remains an open question.
An alternative avenue of investigation has been to assess whether there is a direct, functional relationship between epigenetics and genetics at particular risk alleles.
Other evidence of a direct functional relationship comes from an fMRI study of resting state connectivity, in which fluctuations in BOLD signal are correlated between regions.
Janga et al. [ 59] suggest that the conservation might be accounted for by the general importance of macromolecular biosynthesis rather than from a direct functional relationship.
Admittedly, those relationships are through association, which does not necessarily indicate a direct functional relationship for the outcome or phenotype being studied.
Similar(51)
Early immunohistochemistry studies have shown colocalization of macrophages with apo A-I and/or apo E in human coronary artery lesions (73, 76), but the direct functional relationship between SR-A and apo A-I in tissues remains to be proven.
Figure 4 shows the subnetwork from the full HIV receptor network that exhibits only the direct functional relationships between seed receptors and predicted surface membrane factors.
Together, these results indicate an epistatic relationship and a direct functional link between shox2 and isl1 in the pacemaking system of zebrafish embryos.
Prognaus uses a direct functional approach (Table 1).
However, a direct functional link remains to be proven.
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