The phrase "a direct functional link" is correct and usable in written English.
It can be used to describe a clear and immediate relationship or connection between two elements, often in technical or analytical contexts.
Example: "The study found a direct functional link between exercise and improved mental health outcomes."
Alternatives: "a clear functional connection" or "an immediate functional relationship".
We demonstrate the utility of this in vitro system in providing a direct functional link between in vivo and in vitro observations with DtxR and mutants of DtxR, which display subtle changes in activity in a manner not previously possible.
Therefore, this will be the first time a direct functional link between Akt and Bmi-1 is made.
Smad 2/3 proteins are the downstream effectors of TGFβ signaling and the target of MAPK/ERK pathways as well, we therefore wanted to investigate whether cystatin C may have a direct functional link to these signalling pathways.
Recently, cystatin C was identified as a novel substrate for MMP2 in cell-based proteomic analysis, suggesting that there is a direct functional link between MMP2 and cystatin C [40].
Since we have established a direct functional link between cystatin C and Erk2 activity, and we have demonstrated that PCa patients with low cystatin C levels and concomitant high levels of AR showed a tendency towards a worse outcome as compared to patients with high cystatin C and high AR levels, we therefore wanted to assess the cellular and molecular association between cystatin C and AR.
However, a direct functional link remains to be proven.
While the number of CHIKF patients in our study is too small to demonstrate any direct functional link between TLR3 gene polymorphisms and CHIKV disease outcomes, our findings suggest a possible relationship between the presence of TLR3 SNPs, rs3775292 and rs6552950 with an increased risk of CHIKV disease occurrence.
Suggesting a more direct functional link between the actin cytoskeleton and G-proteins, Gβγ subunits were found to be physically associated with actin filaments in several cell lines [40].
The direct functional link between CK-B activity and cell shape changes was clarified by our cell spreading and migration assays, in which ablation of CK-B slowed down these processes in both astrocytes and MEFs.
Strong negative frequency dependent selection acting on MAT A was suggested to maintain the high levels of molecular variation (Engh et al. 2010b); however, no direct (functional) link was made between the genotype and MAT alleles.
The direct functional link between Setd8 and p63 remains elusive but recent studies showed that Setd8 methylates p53 at lysine 382 and thereby suppresses p53-mediated transcription in vitro (Shi et al, 2007).
