The phrase "a direct disruption" is correct and usable in written English.
It can be used to describe an interruption or disturbance that is immediate and straightforward in nature.
Example: "The storm caused a direct disruption to the power supply, leaving many homes without electricity."
Alternatives: "an immediate interruption" or "a clear disturbance."
"For anybody that wants to follow in our footsteps, this is a direct disruption of freedom of speech, this is like a muzzle," Fara said, adding that they will keep fighting the ruling.
A direct disruption or punctation of the vertebral artery, however, will not be avoided by IOUS.
Only 8% of Type 2 mutations were predicted to directly disrupt the pVHL-HIFα interface, compared with 33% of Type 1 mutations, suggesting that a direct disruption of HIFα binding may not be necessary to cause PCCs and that an HIF-independent mechanism underlies the pathogenesis of PCCs (further material in Supplementary Material, Discussion).
Recently, Lu et al. [26] have proposed that the influence of AuNPs on CYP2B1-mediated stereoselective metabolism may be due to a combined effect of direct disruption of enzyme conformation and indirect alteration in ionic strength of microenvironment for co-factor production.
This indicates that artemisinin and its related derivative OZ209 kill malaria by a similar mechanism all through direct disruption of mitochondrial functions.
We therefore tested whether restoration of physiological pHe could immediately rescue PrlR signaling, which would be consistent with a primary mechanism of direct disruption of ligand binding.
As shown in Fig. 5 A, Dynasore did not inhibit the action of PLO by direct disruption of the CDC or by protecting the red blood cells.
In aggressive PCa, aberrantly high expression of PCAT-114 inhibited SWI/SNF-mediated epigenetic regulation, due to direct disruption of SNF5 activity, a core unit of the SWI/SNF complex [ 74].
Many retrotransposons retain the ability to move (transpose) to new locations in the genome, a potentially deleterious phenomenon that can result in direct disruption to coding regions [ 2, 3].
Directly ionizing radiation (e.g., a beam of protons, alpha particles, or beta particles) causes direct disruption of the atomic or molecular structure of the tissue through which it passes.
However, an alternative possibility is that mutations in Atmin may lead to direct disruption of the actin-myosin cytoskeleton, since abnormal cytoskeletal organization was observed in the homozygous kidneys.
