The phrase "a direct alteration of" is correct and usable in written English.
It can be used when discussing changes made to something, emphasizing that the change is straightforward and unambiguous.
Example: "The report included a direct alteration of the original data, which significantly impacted the results."
Alternatives: "a straightforward modification of" or "an explicit change to".
Moreover, a direct alteration of mitochondria in flight muscles of old flies has also been recently observed [ 39].
These results suggest that influences of Pb on chondrogenesis may also be partially dependent on a direct alteration of AP1 signaling.
If and how the manipulation of AMPs or a direct alteration of gut microbiota might be a preventative strategy in chronic inflammation and inflammation induced colon cancer has yet to be determined.
Recently, it was suggested for direct toxicity mechanisms of nanoparticles to induce a direct alteration of cellular exchanges with the media due to particles binding on cell membrane [ 21].
If and how the manipulation of AMP expression or a direct alteration of gut microbiota might be a preventative strategy in inflammation induced colon cancer, provides nonetheless interesting questions for supplementary future research.
We have found that Pb affects neither basal BMP-2 nor TGF-β signaling; thus it is unlikely that the effect of Pb on chondrogenesis is related to a direct alteration of these signaling pathways.
Sequencing of insertion sites indicates that each is inserted into a repetitive region which could impact expression of affected genes but direct alteration of floral homeotic gene sequences was not detected.
Oxidative stress has been associated with the disruption of tight junctions by several mechanisms such as the elevation of oxidized membrane lipids that alter the localization of tight junction proteins and the direct alteration of claudins extracellular redox sensitive motifs [ 37– 39, 64].
However, it is clear that genetic diversity drives diverse, intricate, and multi-faceted immune responses at the isoform, gene, and pathway levels through direct alteration of gene sequences, indirect regulation of expression, or a combination of both.
A heterologous gene expression system allows strain improvement to produce new metabolites by direct alteration of the biosynthetic pathway.
Overall, the researchers found that about 14percentt of the losses were caused by direct alteration of the landscape by activities such as logging and land-clearing.
