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The decision also reflects a dire shift in momentum on the battlefield.
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"We're in a dire situation in this country," Brotherton said, quietly.
Malnutrition is a dire issue in the developing world.
This "is a dire emergency in need of an immediate response," Northup had said.
This is a vast shift in taste.
"It's a major shift in psychology".
This marks a distinct shift in worldview.
It was a notable shift in priorities.
It marks a massive shift in attitude.
Bring a paradigm shift in your consciousness.
A shift in research focus for glioma is also justified with dire statistics: glioblastoma multiforme (GBM) is the most common, and unfortunately, also the most highly malignant glioma.
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