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Whereas injection of HSF-1 into an SBMA mouse model resulted in only small effects in neurons, Hsp90/HSPC inhibition by 17-AAG, geranylgeranylacetone (GGA) and geldanamycin (GA) not only substantially increased lifespan, but also diminished aggregates (Fig. 2).
A possible explanation could be that different plant species (N. tabacum or N. benthamiana) were utilised for purification, and in the case of N. benthamiana extracts, Nef showed a diminished tendency to aggregate and precipitate in the insoluble protein fraction.
Because a diminished BBC would diminish Britain.
But Mr Zhou seems a diminished figure.
A diminished JA-Zenchu would help.
What defines a diminished person?
Complicating matters is a diminished fan base.
Today the chancellor is a diminished figure.
An invisible past is a diminished one.
Today, they seemed a diminished lot.
Without it, he is a diminished figure.
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