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The phrase "a difficult upbringing" is correct and usable in written English.
You can use it when discussing someone's childhood experiences that were challenging or adverse.
Example: "Despite having a difficult upbringing, she managed to achieve her dreams and inspire others."
Alternatives: "a challenging childhood" or "a troubled upbringing."
Exact(44)
Hamm had a difficult upbringing.
He had a difficult upbringing.
Had a difficult upbringing and was at one stage sleeping rough in Tehran.
The author makes light of a difficult upbringing; he romps through life's many travails.
Mr. Allin, who died in 1993, had had a difficult upbringing with his religiously observant father.
The judge heard that Farquharson had autism and a difficult upbringing.
Similar(16)
"She had endured a very difficult upbringing - no father, an over-controlling but emotionally-distant mother, a disliked stepfather and proximity to great sadness and cruelty in her New York life.
"I had a very difficult upbringing," he explains.
I'm [a woman] from a fairly difficult upbringing who also happens to do other kinds of things.
It was a loving but difficult upbringing, Guirgis says, and "she grew up in a household terrified of intimacy and marriage". Nearly 40 and still single, she was volunteering as an adviser to foreign exchange students when a grateful Egyptian told her to call his family if she were ever inclined to go to Cairo.
Court papers described his difficult upbringing: a disabled mother addicted to heroin who, in a deposition, said she could not read; walls and windowsills containing enough lead to poison the children and leave them incapable of leading functional lives; a young man who was four grade levels behind in reading.
More suggestions(16)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com