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The phrase "a difficult treatment of" is correct and usable in written English.
It can be used when discussing a complex or challenging analysis or interpretation of a subject or topic.
Example: "The author provides a difficult treatment of the philosophical concepts that underpin the narrative."
Alternatives: "a challenging analysis of" or "a complex examination of".
Exact(1)
Low infectious doses (10 to 100 bacteria, [ 1]), transmission through aerosols, and a difficult treatment of the disease by antibiotics, have led Brucella to be classified as potential bioterrorism agents.
Similar(59)
Sarkar (1998) presents a sophisticated (and technically quite difficult) treatment of arguments against heritability.
The surgeon's expectation of a difficult cholecystectomy, including treatment of common bile duct stones, might also affect the timing of surgery.
Physicians treating newly incapacitated patients often must help navigate surrogate decision-makers through a difficult course of treatment decisions, while safeguarding the patient's autonomy.
See related letter by Lott, Physicians treating newly incapacitated patients often must help navigate surrogate decision-makers through a difficult course of treatment decisions [ 1].
"She had a tremendous sense of dignity in the face of often difficult treatment," Ms. Jones said.
During the two years of difficult treatment, I remember thinking, "Isn't there any other way?
Since early detection of electrocution is difficult, treatment is usually implemented late, which reduces its effectiveness.
Hospital-acquired pneumonia represents one of the most difficult treatment challenges in infectious diseases.
Not only does the presence of delirium often complicate and render more difficult the treatment of a serious illness, but also it carries the serious possibility of permanent irreversible brain damage', Engel and Romano [ 1 ].
Patients with newly diagnosed early stage prostate cancer (PCa) face a difficult choice of different treatment options with curative intention.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com