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With a data-driven approach missing data is a difficult problem to tackle, except with the obvious method of capturing more data.
Moreover, our eQTL results showed association with only the isoform 1 of the gene, but not with the isoform 2. Our results could suggest a possible link between alternative splicing/ isoform expression at this locus and IOP regulation, but tissue specificity is likely to remain a difficult problem to tackle when studying expression of genes involved in ocular phenotypes.
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A: Education in conflict areas is a really difficult, complex problem to tackle.
This is an important problem to tackle.
It is well known that, in order to tackle a difficult problem, an algorithm has to incorporate all of the available information on the problem domain.
But the sheer complexity of the problem has made it a difficult beast to tackle and efforts have been sporadic so far.
Now that the product is starting to look good and will target an international audience, the team will have to tackle a difficult problem: creating a flourishing community around recipes.
Carmack is doing what he loves most at Oculus, according to Iribe, which is tackling a difficult problem that's "right on the edge of reality".
No doubt Blue Apron is tackling a difficult problem.
The examples I shared are all interesting ways in which companies out there are tackling a difficult problem of habit change.
When tangling with the short-term missing data problem, this problem is difficult to tackle since the model cannot be estimated stably.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com