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Micro-mixing of liquids is a difficult problem since the mixing performance is governed by the slow diffusive mass transfer.
Learning to act in a multiagent environment is a difficult problem since the normal definition of an optimal policy no longer applies.
This is a difficult problem, since the linearized operator has a non-trivial kernel.
In the final analysis, accurate and precise landmarking remains a difficult problem since, except for a few, the landmarks do not necessarily correspond to high-gradient or other salient points.
No doubt that the evaluation of the performance of a multi-target tracking system is a difficult problem, since the performance of the method is highly criterion, scenario, and parameter dependent.
However, construction of an antibody repertoire is a difficult problem since antibody genes in antigen stimulated B-lymphocytes are not directly encoded in the germline but are diversified by somatic recombination and mutations (Wine et al. 2013).
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F1 hybrids present a more difficult problem since they cannot be detected by a congruence analysis such as our bipartition scoring approach.
Yet 'the extent to which Toolco and its principal officers can be held directly or principally responsible for TWA's present capital structure poses a most difficult problem,' since '(n)umerous factors..
This is a very difficult problem, since the solution space consists of all the different L! encoding orders.
Thus Russell has set himself a rather difficult problem, since it is not at all clear that there can be any true propositions that are not, in some sense, propositions about what is, has been or will be.
The disadvantage, however, is that the determination of the "best" motif cannot be guaranteed and is often a very difficult problem since finding global maximum of any continuous non-convex function is a challenging problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com