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The phrase "a difficult issue with" is correct and usable in written English.
It can be used when discussing a challenging topic or problem that involves a particular subject or aspect.
Example: "The team is currently facing a difficult issue with the project's timeline and resource allocation."
Alternatives: "a challenging problem regarding" or "a complex matter involving".
Exact(1)
However, the characterisation of neck lymph nodes remains a difficult issue with anatomy-based imaging methods, and DWI may be of particular value in this regard.
Similar(52)
This is a difficult issue for most people to deal with when they have all the time they need to think it over.
Despite these political criticisms, fraud was a difficult issue to politicize completely.
"The Twitter thing is a difficult issue and there's a line to tread.
However, without proper qualifications, this appears to be a difficult issue for the nomads.
But today's mega-profits will once again raise a difficult issue.
Other analysts said the United States should not use a specific grievance over housing units to press a broad range of extremely difficult issues with Israel.
"The Glazer ownership is a particularly difficult issue for supporters," Drasdo said in an interview.
With respect to the primary chain, this is a more difficult issue.
This is a more difficult issue to resolve.
"It's a very difficult issue because there are conflicting rights here," Martijn said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com