"Enforcing age restrictions on the Internet is a difficult issue, especially when many reports have shown parents want their children to access online content and services," it wrote, referring to research that shows that preteens sign up for Facebook with their parents' help.
Case-control expression analysis in a degenerative disease like PD poses difficult issues when attempting to uncover pathways contributing to disease initiation.
"It's a very difficult case for a number of reasons; not the least is the nebulous nature of the charges and the inherently difficult issues when you're talking about a person executing his First Amendment right to promote a particular politician," said Michael D. Monico, a former federal prosecutor who is now a criminal defense lawyer in Chicago.
One of the most important and difficult issues when defining the guidelines was to establish what constitutes a chemical mention and what does not.
"Water is one of our most difficult issues when we are evaluating large-scale projects," said Lorelei Oviatt, the division chief for the Kern County Planning Department.
When there is a difficult issue we will need governments with the courage to lay them on the table".
When there is a difficult issue to address like mass killings, well-intentioned people and clergy will say the same thing: We can't understand why, but God's love will help us through it.
More than four in five of the general public would expect a business leader to lie when confronted with a difficult issue, according to the PR firm's trust barometer.
"I know that some people maintain that only trans actors should play trans roles, and it's a difficult issue, but certainly there is greater flexibility when the character is undergoing the process of transition," she said.
In detailed interviews with 31,000 people around the world, fewer than one in five people believe a CEO or a top government official will tell the truth when confronted with a difficult issue.
