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In the study of melphalan it is important to recognize that the remission status is a difficult end point for evaluation as it is also influenced by an effect of the induction therapy and maintenance.
Hyperspectral dimensionality poses a difficult challenge for rigorous performance evaluations because of the unavailability of the number of test samples required by theories.
TUNEL evaluation and scoring is a difficult task for clinical application.
Although it is very difficult to perform a valid evaluation for a service that practically refers to the entire web population, the results from the evaluation underpin the motive of this work, i.e., the fact that large-scale web search engines encounter limitations when employed by users featuring specific search modes.
It's a difficult start for us".
That was a difficult summer for everyone.
It was a difficult time for Aaron.
Balance is a difficult concept for Galliano.
"It was a difficult period for me.
"It's a difficult decision for Levy.
This is a difficult problem for retributivists.
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