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The phrase "a difficult disease and" is correct and usable in written English.
It can be used when discussing the challenges associated with a particular disease, often leading into further explanation or comparison.
Example: "Living with a difficult disease and managing its symptoms can be overwhelming for many patients."
Alternatives: "a challenging illness" or "a tough condition".
Exact(1)
The companies say they have a generally safe record in treating a difficult disease and are fighting lawsuits in which some patients claim harm.
Similar(59)
2 Mesothelioma is generally known to be a rare cancer, although the evidence‐based science on this cancer is limited, and it is a difficult disease to diagnose and to treat. 4 Patients typically present with breathlessness and chest pain with pleural effusions.
Cancer is well known to be a difficult disease, affecting patients and their families both physically and emotionally.
These problems make non-CF bronchiectasis a difficult disease to treat and there is currently no approved antibacterial therapy for long-term treatment [ 3– 6].
Commonly, the course of disease will include periods of remission and flares and the disease presentation is heterogeneous among patients making SLE a difficult disease to characterize, diagnose, and study.
When not properly treated, dysentery can lie dormant for years and lead to hepatic amoebiasis, a difficult disease to diagnose, but once diagnosed readily cured.
Historically, metastatic renal cell carcinoma (mRCC) has been a difficult disease to manage, because of its resistance to chemotherapy and radiotherapy.
Public pain remains a difficult disease to apprehend because of the anatomic complexity of the pubic region and the frequent combination of several pathological conditions.
We're finding this is a difficult disease to treat".
That's significant because Cushing's afflicts only one in a million humans, making it a difficult disease to study.
An estimated 26 million Americans have diabetes, a difficult disease to treat that often requires patients to try a variety of drugs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com