The phrase "a difficult and significant" is correct and usable in written English.
It can be used to describe a task, issue, or concept that is both challenging and important.
Example: "The project we are undertaking is a difficult and significant challenge that will require all of our resources and expertise."
Alternatives: "a challenging and important" or "a tough and meaningful".
Today its style guide states, "Terrorism is a difficult and emotive subject with significant political overtones... we try to avoid the use of the term 'terrorist' without attribution".
In a sermon Monday in Guayaquil, Ecuador, the pope said the bishops will "consider concrete solutions to the many difficult and significant challenges facing families in our time".
Conclusion: The parenting role of the father to his daughter may be one of the most difficult and significant of human relationships.
Content issues: I think the manuscript would benefit from a description of the other option of intubating a patient with a true difficult airway and significant pulmonary compromise: i.e. place a single lumen tube to improve oxygenation and ventilation, then exchange over an airway exchange catheter (Cook).
The design of new and more selective inhibitors of FGFRs, which might be reduced off-target and side effects, is a difficult yet significant challenge.
"This is a difficult area with significant legal, administrative and policy implications with respect to which we have little enforcement history," wrote Steven T. Miller, the I.R.S. deputy commissioner for services and enforcement.
This is a difficult question with significant methodological challenges [ 8], and divergent answers can be found within empirical research [ 9- 11].
However, who of us does not have a difficult significant other in the distant past?
Connecticut has been a consistent contender in the past two decades, but Jim Calhoun suffered through a difficult season despite significant talent.
Expanding on Obama's remarks, a White House official said Obama's remarks were reflecting his admiration for the length and depth of Bernanke's commitment to serve as Fed chair in a difficult period and at a significant personal sacrifice.
