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Unfortunately, the activity-based purification of unidentified proteins from serum has proven often to be a difficult and laborious task.
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Research has shown that the implementation of integrated care is a very difficult and laborious task [ 66, 67], especially regarding the proposed model because it focuses on integration across the entire continuum of care for all frail elderly.
Why embark on such a difficult and laborious journey?
A traditional and laborious task of the reviewer of a crystal structure report was the independent validation of the reasonableness of the submitted model.
Crossing the Sahara, where the truck repeatedly got stuck in the sand, proved both a dangerous and laborious task.
However, to distinguish incorrect gene models from alternative splicing is a challenging and laborious task.
Finding all relevant publications on a topic using PubMed-type databases is a long and laborious task.
The construction of physical maps for a 5 Gb size genome is a complex and laborious task.
The traditional way of collecting and managing the data in behavioral field studies has been a tedious and laborious task.
Realist reviews can yield valuable insight for policy makers and program planners, but conducting them is a complex and laborious task.
However, the de novo sequencing of the whole genome of a non-model plant is still a challenging and laborious task [ 5].
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