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The linear regression model indicated that there was no evidence that the rate at which ARHAs were increasing was different in EI compared with non-EI sites or that the intervention had a differing effect on these sites.
Further, the effects of the patient's previous treatment (period A) may have a differing effect on response to the second treatment (period B), akin to the carryover concept in a crossover trial.
Thalidomide has been observed to increase PSA expression in a prostate cancer cell line in vitro (Dixon et al, 1999), so the PSA reduction observed in some patients probably reflects a differing effect on tumours in vivo.
Similar(57)
67– 70 Seizure disorders of differing etiologies have differing effects on cognition.
Although there is certainly some decreased expression/activity of CYPs in cirrhosis, the mechanism of decreased hepatic drug metabolic clearance in vivo is more complex and may have differing effects on different enzymes.
We detected uRap1a in both MCF7 and MDA-MB-231 cells after treatment with ZOL, suggesting that variable uptake of the drug is not an explanation for the differing effects on follistatin.
As the processes of direct and indirect fracture healing are radically different, both physical modalities (e.g. ultrasound) and pharmacological agents may have differing effects on the different types of fracture repair.
Yet, the situation is complicated by the fact that different fatty acids have differing effects on the various lipoproteins that carry cholesterol.
When the growth rates of the aragonite and calcite seeds were measured in the presence of a magnetic field at temperatures above room temperature, the synergetic effects were significant but with differing effects on the different seeds.
HBO has the potential to have many differing effects on a chronic wound and it may not be reasonable to assume that this therapy should be used to fully heal a wound.
There is evidence indicating different PIK3CA mutations have differing effects on PIK3CA signaling and AKT phosphorylation, and therefore may determine prognosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com