These results suggest that extrinsic factors responsible for an efficient mesenchymal differentiation should be investigated more thoroughly, since acquisition of mesenchymal differentiation correlates with the characteristics of cell senescence.
While mutations and other genetic alterations can speed up cancer cell growth at a certain degrees of metastasis, the amount of EMT defining a particular degree of differentiation should be controlled by epigenetic changes [17].
If the threshold is related to the noise level, and if differentiation requires a change of the threshold, then differentiation should be accompanied by a change in the noise level.
With IP wars raging across the world, differentiation should be a major focus.
Obviously, materials must be biocompatible, nontoxic, nonimmunogenic, and noncarcinogenic, should facilitate cellular adhesion, proliferation, organization, and differentiation, should be characterized by a suitable degradation rate and resist bacterial colonization [ 12].
However, such differentiation should be interpreted as a kind of transcriptomic robustness and needs to be distinguished from regular adaptation to environmental changes representing short-time flexibility for adaptation.
In this paper, we advocate that when designing such deadline-aware rate control schemes, a simple principle should be followed: flows with different deadlines should be differentiated in their bandwidth allocation/occupation, and the more traffic load, the more differentiation should be made.
It predicts that later Amerindians differentiated locally from Paleoamericans, and therefore, following the range expansion model, their morphological differentiation should be proportional to their geographic proximity.
The development of strategies for improving cell survival and differentiation should be encouraged, such as preconditioning procedures with cell electrostimulation or by using tissue engineering in order to create a bioartificial myocardium.
