Exact(2)
Dystrophy and chronic irritation are probably a favorable condition for inducing nuclear atypia in the deepest layers of epithelium, resulting in high grade vulvar intraepithelial neoplasia (VIN) of a differentiated type.
It is commonly admitted that VIN associated with lichen sclerosus is a differentiated type and that overexpression of p53 is present, contrary to what happens in undifferentiated type VIN, induced by HPV, and in which overexpression of p16 is encountered [ 5].
Similar(58)
Therefore, it would seem that in the majority of cases, C-Ca arise as a differentiated-type tumour in the incipient phase of carcinogenesis.
It is interesting to observe that two types of redundancies have been observed in real cells, when moving in a signal-driven way from an intermediate type A to a more differentiated type B: in some cases the transition can be achieved by acting on different genes of A [38], and in other cases B may be reached also by acting on a cell type C which does not belong to the lineage of A [23][39].
Slices of tumour cultured in the presence of testosterone showed a morphological change to a more differentiated type of neoplasm whereas explants cultured in the absence of steroid hormone, or with stilboestrol diphosphate, showed no change.
Interestingly enough, this histological "conversion" into a more differentiated type at the metastatic location has been observed in a few series of patients with GCTs [ 6].
Conversely, expression of aquaporin 5 (aqp5), a terminally differentiated type I cell marker, was reduced in Cby−/− lungs.
GXF97, MKN-28, SC-09-JCK, and NCI-N87 were categorized as tubular adenocarcinoma, known as a well differentiated type.
This also guarantees a transfer of the overall methylation pattern to the daughter cells during mitosis, producing a stable differentiated type of tissue.
In contrast, the intestinal phenotype is a very well differentiated type, with low proliferative activity and a lack of MSI [ 17].
"[I]t appears that this was not an investment by Mr. Miller simply to get a new and differentiated type of audio product than Bose could deliver, for his personal use," the complaint explains, "but rather an attempt to gain early access to a competitor's technology".
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